The Problem of Lipohilicity
Medicinal chemists are constantly balancing the physical chemical properties of their target compounds to discover the next successful medicine.
and is directly proportional to an increase in secondary pharmacology.
The Problem of Polarity
Conversely, adding polarity often reduces metabolic clearance, increases aqueous solubility and reduces the risk of picking up secondary pharmacology.
However, these benefits often come at the expense of cell potency and cell membrane flux.
The Balance
These opposing issues lead to a scenario dominated by the need to finely balance physiochemical properties 損olarity, lipophilicity,
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