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  • Mr.Medchem

    Tel: 1858 729 3957

  • Please mention that you found the contact information on LookChem.

  • Tel:1858 729 3957
  • Fax:1858 246 7373
  • Province/state:CA
  • City:San Diego
  • Street:3736 Cascade Court San Diego 92122 CA USA
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  • The Problem of Lipohilicity
    Medicinal chemists are constantly balancing the physical chemical properties of their target compounds to discover the next successful medicine.

    Adding lipophilicity improves potency but increases metabolic clearance, reduces aqueous solubility,

    and is directly proportional to an increase in secondary pharmacology.


    The Problem of Polarity
    Conversely, adding polarity often reduces metabolic clearance, increases aqueous solubility and reduces the risk of picking up secondary pharmacology.

    However, these benefits often come at the expense of cell potency and cell membrane flux.


    The Balance
    These opposing issues lead to a scenario dominated by the need to finely balance physiochemical properties 損olarity, lipophilicity,

    charge and molecular weight? issues that all medicinal chemists are familiar with.


    Medchem Monomers has the Solution
    MedChem Monomers aims to provide low molecular weight monomers with a higher degree of polarity than the median

    (see figure) to increase the chemical diversity of the common monomer sets

lookchemhot product CAS New CAS Cas Database Article Data Chemical Catalog

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Mr.Medchem
Tel:1858 729 3957